Apl sjukdom

Det ar viktigt att tidigt uppmarksamma DS. Typiska symtom och fynd ar dyspne, lunginfiltrat, feber, snabb viktuppgang, pleura- eller perikardvatska, hypotension och/eller njursvikt. Patienter med 4 eller fler symtom/fynd enligt ovan bedoms ha svar DS, 2–3 symtom/fynd bedoms som mattlig DS. 1 vesanoid 2 Akut promyelocytleukemi ar en ovanlig sjukdom med initialt hog mortalitet framforallt i blod- ningar. Sa snart diagnosen misstanks ska patienten uppfattas som ”medical emergency”. (Evidensniva IV) 1 Den kliniska misstanken om APL ar i alla lagen grunden for tidig start av ATRA- terapi. 3 acute promyelocytic leukemia 4 Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia (AML). It happens when there are too many of the blood-forming cells called promyelocytes in the blood and bone marrow. A buildup of promyelocytes leads to a shortage of other kinds of blood cells, including red cells, white cells, and platelets. 5 Acute promyelocytic leukemia (APL) is one of several subtypes of acute myeloid leukemia, a blood cancer that originates in a person's bone marrow. APL is caused by a genetic mutation, but it is not a hereditary condition. APL is a potentially life-threatening disease; however, it is the most curable form of adult leukemia. 6 APL is a relatively rare type of leukemia that causes a buildup of immature white blood cells in your blood and bone marrow. It’s caused by genetic changes in the cells that create blood cells. 7 leukemi arftligt 8 Koagulopati med risk for framst allvarliga blodningar men ibland aven tromboser ar vanligt vid APL. Risken ar storst vid sjukdomsdebuten och i behandlingens. 9 Akut omhandertagande vid misstanke om APL. Akut promyelocytleukemi ar en ovanlig sjukdom med initialt hog mortalitet framforallt i blod- ningar. 10 arsenik behandling 11 akut lymfatisk leukemi 12